Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Phytother Res. 2020 Aug;34(8):2023-2031. doi: 10.1002/ptr.6655. Epub 2020 Mar 6.
The present study sought to investigate the effect of micronized resveratrol supplementation on serum levels of asymmetric de-methyl-arginine (ADMA) and paraoxonase-1 (PON1) activity in patients with type 2 diabetes (T2D). In this double-blinded randomized trial, 76 patients with T2D were recruited. Participants were randomly assigned to consume 1,000 mg resveratrol or placebo capsules (methylcellulose) per day, for 8 weeks. Serum levels of ADMA and PON1 enzyme activity were measured at the beginning and end of the intervention using the enzyme-linked immunosorbent assay method. In total, 71 participants completed the study. Our results showed that resveratrol significantly decreased serum levels of ADMA (-0.16 ± 0.11, p < .001) and improved PON1 enzyme activity (15.39 ± 13.99, p < .001) compared with placebo, after adjusting for confounding factors (age, sex, and baseline body mass index). Our findings suggest that 8-week resveratrol supplementation may produce beneficial effects on serum levels of ADMA and PON1 enzyme activity in patients with T2DM. However, further research is needed to confirm the veracity of these results.
本研究旨在探讨补充白藜芦醇对 2 型糖尿病（T2DM）患者血清不对称二甲基精氨酸（ADMA）水平和对氧磷酶-1（PON1）活性的影响。在这项双盲随机试验中，招募了 76 名 T2DM 患者。参与者被随机分配每天服用 1000 毫克白藜芦醇或安慰剂胶囊（纤维素），持续 8 周。采用酶联免疫吸附法测定干预前后血清 ADMA 水平和 PON1 酶活性。共有 71 名参与者完成了研究。结果表明，与安慰剂相比，白藜芦醇显著降低了血清 ADMA 水平（-0.16±0.11，p<.001），并改善了 PON1 酶活性（15.39±13.99，p<.001），调整混杂因素（年龄、性别和基线体重指数）后。我们的研究结果表明，8 周的白藜芦醇补充可能对 T2DM 患者的血清 ADMA 和 PON1 酶活性产生有益影响。然而，需要进一步的研究来证实这些结果的真实性。
