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使用检查点抑制剂使脊髓髓内转移灶消退:一例报告

Regression of an intramedullary spinal cord metastasis with a checkpoint inhibitor: a case report.

作者信息

Phillips Kester A, Gaughan Elizabeth, Gru Alejandro, Schiff David

机构信息

Department of Neurology, Division of Neuro-Oncology, University of Virginia, Charlottesville, VA 22908 USA.

Department of Medicine (Hematology-Oncology), University of Virginia, Charlottesville, VA 22908 USA.

出版信息

CNS Oncol. 2017 Oct;6(4):275-280. doi: 10.2217/cns-2017-0007. Epub 2017 Oct 16.

Abstract

Intramedullary spinal cord metastasis is an increasingly common diagnosis in patients with cancer largely owing to new imaging techniques and the increase lifespan of patients with malignant tumors. The diagnosis confers significant morbidity and a poor prognosis. Mainstay palliative treatment options include corticosteroids, fractionated radiotherapy and surgery in select cases. In the modern era of immunotherapy for the treatment of several tumor types, the efficacy of these agents against parenchymal CNS tumors remains unanswered. Here, we report a case of regression of an intramedullary spinal cord metastasis with a checkpoint inhibitor.

摘要

脊髓髓内转移在癌症患者中是一种越来越常见的诊断,这主要归因于新的成像技术以及恶性肿瘤患者寿命的延长。该诊断会导致显著的发病率和不良预后。主要的姑息治疗选择包括皮质类固醇、分次放射治疗以及在特定病例中进行手术。在针对多种肿瘤类型进行免疫治疗的现代,这些药物对实质性中枢神经系统肿瘤的疗效仍未明确。在此,我们报告一例使用检查点抑制剂使脊髓髓内转移灶消退的病例。

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