Faisal Waleed, Farag Fatma, Abdellatif Ahmed A H, Abbas Abdelhamid
Department of Pharmaceutics, Faculty of Pharmacy, Minia University, Egypt.
Department of Pharmaceutics, Faculty of Pharmacy, Qassim University, Buraydah, Saudi Arabia.
Curr Drug Deliv. 2018 Feb 14;15(2):167-185. doi: 10.2174/1567201814666171013145958.
Undesirable taste is an important problem for patient compliance. Several oral pharmaceuticals and bulking agents have disagreeable and bitter-tasting components. The Bitter taste characteristics found in such systems have been eliminated or minimized by the development of numerous formulations with improved performance and acceptability especially in children and elderly patient. This review is mainly concerned with the bitter-masking techniques published in peer-reviewed journals and will shed light on different methods of masking undesirable taste of the drugs, and their pharmaceutical applications. Hence, nearly no reference will be made to the techniques published as patent applications.
不良味道是影响患者依从性的一个重要问题。几种口服药物和填充剂含有令人不悦的苦味成分。通过开发众多性能和可接受性更佳的制剂，尤其是针对儿童和老年患者的制剂，此类体系中发现的苦味特征已被消除或降至最低。本综述主要关注发表在同行评审期刊上的苦味掩蔽技术，将阐明掩盖药物不良味道的不同方法及其药学应用。因此，几乎不会提及作为专利申请发表的技术。
