Francoia Jean-Patrick, Vial Laurent
WestCHEM, School of Chemistry, The University of Glasgow, Glasgow, G12 8QQ, UK.
Institut des Biomolécules Max Mousseron, UMR 5247 CNRS-Université de Montpellier-ENSCM, Place Eugène, Bataillon, 34296, Montpellier cedex 5, France.
Chemistry. 2018 Feb 26;24(12):2806-2814. doi: 10.1002/chem.201704147. Epub 2018 Jan 17.
Less than a decade ago, dendrigrafts of poly-l-lysine (DGLs) joined the family of polycationic dendritic macromolecules. Resulting from the iterative polycondensation of an N-carboxyanhydride in water, four generations of the dendrigraft can be obtained on a multigram scale and without chromatographic purification. DGLs share features with both dendrimers and hyperbranched polymers, but turned out to have unique biophysical and bioactive properties. The macromolecules-in their native form or functionalized-have been extensively characterized by various analytical and computational methods, and have already found numerous applications in the biomedical field, such as drug and gene delivery, biomaterials, tissue engineering, bioimaging, and biosensing. Despite a growing interest for DGLs, there is still plenty of room for further exciting developments that could result from a better exposure of these macromolecules, which is the ambition of this short review.
不到十年前，聚-L-赖氨酸树枝状接枝物（DGLs）加入了聚阳离子树枝状大分子家族。通过N-羧基酐在水中的迭代缩聚反应，可以在多克规模上获得四代树枝状接枝物，且无需色谱纯化。DGLs兼具树枝状大分子和超支化聚合物的特征，但已证明具有独特的生物物理和生物活性特性。这些大分子无论是天然形式还是功能化形式，都已通过各种分析和计算方法进行了广泛表征，并且已经在生物医学领域有众多应用，如药物和基因递送、生物材料、组织工程、生物成像和生物传感。尽管对DGLs的兴趣日益浓厚，但由于对这些大分子有更好的了解，仍有很大的进一步发展空间，这正是本简短综述的目标。
