Division of Hematology/Oncology, Department of Pediatrics.
Division of Hematology/Oncology, Department of Medicine.
J Clin Invest. 2017 Nov 1;127(11):3921-3922. doi: 10.1172/JCI97707. Epub 2017 Oct 16.
The hematopoietic system declines with age, resulting in decreased hematopoietic stem cell (HSC) self-renewal capacity, myeloid skewing, and immune cell depletion. Aging of the hematopoietic system is associated with an increased incidence of myeloid malignancies and a decline in adaptive immunity. Therefore, strategies to rejuvenate the hematopoietic system have important clinical implications. In this issue of the JCI, Poulos and colleagues demonstrate that infusions of bone marrow (BM) endothelial cells (ECs) from young mice promoted HSC self-renewal and restored immune cell content in aged mice. Additionally, delivery of young BM ECs along with HSCs following total body irradiation improved HSC engraftment and enhanced survival. These results suggest an important role for BM endothelial cells (ECs) in regulating hematopoietic aging and support further research to identify the rejuvenating factors elaborated by BM ECs that restore HSC function and the immune repertoire in aged mice.
造血系统会随着年龄的增长而衰退，导致造血干细胞（HSC）自我更新能力下降、髓系偏向和免疫细胞耗竭。造血系统的衰老与髓系恶性肿瘤的发病率增加和适应性免疫的下降有关。因此，使造血系统年轻化的策略具有重要的临床意义。在本期 JCI 中，Poulos 及其同事证明，输注来自年轻小鼠的骨髓（BM）内皮细胞（EC）可促进 HSC 的自我更新，并恢复老年小鼠的免疫细胞含量。此外，在全身照射后输注年轻的 BM EC 与 HSCs 一起，可改善 HSC 的植入并提高存活率。这些结果表明 BM 内皮细胞（EC）在调节造血衰老方面起着重要作用，并支持进一步的研究，以确定由 BM EC 产生的、可恢复老年小鼠 HSC 功能和免疫库的年轻化因子。
