通过醌光还原和三甲基锁在生理条件下实现可见光介导的聚合物链裂解。
Visible-light-mediated cleavage of polymer chains under physiological conditions via quinone photoreduction and trimethyl lock.
作者信息
Truong Vinh X, Li Fanyi, Ercole Francesca, Forsythe John S
机构信息
Department of Materials Science and Engineering, Monash Institute of Medical Engineering, Monash University, Clayton, 3800 VIC, Australia.
出版信息
Chem Commun (Camb). 2017 Nov 7;53(89):12076-12079. doi: 10.1039/c7cc07257k.
PMID:29035405
Abstract
We introduce a click and visible-light triggered unclick approach via thio-bromo reaction and hydroquinone photoreduction/trimethyl lock cleavage for polymer modifications. Both reactions can be carried out in water and at ambient temperature, enabling preparation of bioorthogonal hydrogels for encapsulation and controlled release of various cells.
摘要
我们通过硫代溴反应以及对苯二酚光还原/三甲基锁裂解，引入了一种用于聚合物修饰的点击和可见光触发的去点击方法。这两种反应都可以在水中和室温下进行，从而能够制备用于封装和可控释放各种细胞的生物正交水凝胶。
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