Shafei H, Nashef S A, Turner M A, Bain W H
Department of Cardiothoracic Surgery Western Infirmary, Glasgow, Scotland.
Thorac Cardiovasc Surg. 1988 Aug;36(4):202-5. doi: 10.1055/s-2007-1020078.
During 1986, 343 consecutive patients who underwent isolated coronary bypass grafting were given 10 mg of propranolol three times daily for six postoperative weeks to help prevent supraventricular tachyarrhythmias. The incidence of these arrhythmias in this group was compared to that in a similar group of 337 consecutive patients who underwent coronary surgery in 1984 at the same institution and did not receive propranolol. There was no significant difference in the overall incidence of such arrhythmias between the propranolol group (10.8%) and the control group (10.4%). In preoperatively beta-blocked patients, the arrhythmia incidence in the propranolol group (9.9%) was lower than that in the control group (13.8%) but the difference did not achieve statistical significance. The two groups were also similar with respect to the ventricular response rates at the onset of the arrhythmia and the effectiveness of therapeutic intervention. These results suggest that propranolol in the above dosage does not significantly reduce the incidence of supraventricular tachyarrhythmias after myocardial revascularisation.
1986年期间，343例连续接受单纯冠状动脉搭桥术的患者术后六周每天三次服用10毫克普萘洛尔，以预防室上性快速心律失常。将该组心律失常的发生率与1984年在同一机构接受冠状动脉手术且未接受普萘洛尔治疗的337例连续患者的类似组进行比较。普萘洛尔组（10.8%）和对照组（10.4%）此类心律失常的总体发生率无显著差异。术前接受β受体阻滞剂治疗的患者中，普萘洛尔组的心律失常发生率（9.9%）低于对照组（13.8%），但差异无统计学意义。两组在心律失常发作时的心室反应率和治疗干预效果方面也相似。这些结果表明，上述剂量的普萘洛尔并不能显著降低心肌血运重建术后室上性快速心律失常的发生率。
