Programa de Pós-Graduação em Saúde e Meio Ambiente, Universidade da Região de Joinville - UNIVILLE, Rua Paulo Malschitzki, 10-Zona Industrial Norte, CEP 89201-972, Joinville, SC, Brazil.
Departamento de Medicina, Universidade da Região de Joinville - UNIVILLE, Rua Paulo Malschitzki, 10-Zona Industrial Norte, CEP 89201-972, Joinville, SC, Brazil; Programa de Pós-Graduação em Saúde e Meio Ambiente, Universidade da Região de Joinville - UNIVILLE, Rua Paulo Malschitzki, 10-Zona Industrial Norte, CEP 89201-972, Joinville, SC, Brazil.
Biomed Pharmacother. 2017 Dec;96:642-649. doi: 10.1016/j.biopha.2017.10.047. Epub 2017 Nov 6.
We investigated the effects of chronic administration of crude hydroalcoholic extract (CHE) and crude acetone extract (CAE) obtained from leaves of Eugenia brasiliensis species on hypertriglyceridemia and oxidative stress caused by the chronic administration of coconut oil. Rats received CHE or CAE (50, 100 or 150mg/kg, orally) for 30days, plus coconut oil (2mL, orally) or saline for 15th. Triglyceride levels, liver cell lipid accumulation, thiobarbituric acid reactive substances (TBA-RS), total sulfhydryl content and the activities of antioxidant enzymes catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were evaluated in the blood and liver of rats. Results showed that chronic administration of CHE or CAE was able to prevent hypertriglyceridemia and decrease the lipid droplets in liver cells, as well as the increase in TBA-RS, the reduction in total sulfhydryl content and CAT activity in the blood and prevent total or partial the increase in CAT and reduction in SOD and GSH-Px activities in the liver. These findings indicate that both extracts may have hypolipidemic and antioxidant effects.
我们研究了从 Eugenia brasiliensis 属植物叶片中获得的粗水醇提取物（CHE）和粗丙酮提取物（CAE）对慢性给予椰子油引起的高甘油三酯血症和氧化应激的影响。大鼠接受 CHE 或 CAE（50、100 或 150mg/kg，口服）30 天，同时给予椰子油（2mL，口服）或生理盐水 15 天。评估了大鼠血液和肝脏中的甘油三酯水平、肝细胞脂质积累、硫代巴比妥酸反应物质（TBA-RS）、总巯基含量以及抗氧化酶过氧化氢酶（CAT）、超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GSH-Px）的活性。结果表明，慢性给予 CHE 或 CAE 能够预防高甘油三酯血症和减少肝细胞中的脂质滴，以及增加 TBA-RS、降低血液中总巯基含量和 CAT 活性，并预防 CAT 全部或部分增加以及 SOD 和 GSH-Px 活性降低在肝脏中。这些发现表明，这两种提取物都可能具有降血脂和抗氧化作用。
