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18F-FAZA PET/CT 乏氧显像在高级别胶质瘤放化疗前后的应用

18F-FAZA PET/CT Hypoxia Imaging of High-Grade Glioma Before and After Radiotherapy.

机构信息

From the *Nuclear Medicine Department, IRCCS San Raffaele Scientific Institute; †Radiotherapy Department, San Raffaele Scientific Institute; and ‡Neuroradiology Unit and CERMAC, San Raffaele Scientific Institute and Vita-Salute San Raffaele, Milan, Italy.

出版信息

Clin Nucl Med. 2017 Dec;42(12):e525-e526. doi: 10.1097/RLU.0000000000001850.

Abstract

A 57 year-old man underwent MRI with dynamic susceptibility contrast and dynamic contrast-enhanced perfusion for neurological symptoms suggesting the diagnosis of high-grade glioma. A F-FAZA PET/CT was performed because of the enrollment in a prospective clinical trial. Subsequent radiotherapy treatment has been planned based on conventional imaging; moreover, a F-FAZA PET/CT-guided treatment planning highlighting hypoxic regions has been simulated. After radiotherapy treatment, the man underwent MRI and F-FAZA PET/CT, showing partial response.

摘要

一位 57 岁男性因疑似高级别胶质瘤的神经症状接受 MRI 动态对比增强和动态对比灌注检查。由于参加前瞻性临床试验,进行了 F-FAZA PET/CT 检查。随后根据常规影像学检查计划进行放疗治疗;此外,还模拟了 F-FAZA PET/CT 引导的治疗计划,突出显示缺氧区域。放疗后,该男性接受了 MRI 和 F-FAZA PET/CT 检查,显示部分缓解。

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