Roubalová K, Weinreb M, Roubal J, Kodet R, Koutecký J, Vonka V
Institute of Sera and Vaccines, Prague, Czechoslovakia.
Acta Virol. 1988 Jul;32(4):339-48.
Antibody titres against Epstein-Barr virus (EBV) antigens in children suffering from non-Hodgkin's lymphoma (NHL) were determined. IgG antibody titres against the viral capsid antigen (VCA) and early antigen (EA) exceeded those found in healthy control subjects. On the other hand, antibody titres against EBV-determined nuclear antigen (EBNA complex) were generally lower than in the control group. The most striking phenomenon observed in the patient group was the frequent activation of latent virus infection as revealed by the periodical appearance of anti-EA and IgM class anti-VCA antibodies. Antibody titres against EBV antigens were generally lower among patients with progressing disease than in those with a more favourable course of the illness. The closest relation to EBV based on serological findings, was detected in lymphoblastic lymphomas of Burkitt-type histology, poorly differentiated lymphocytic lymphomas, and in lymphomas localized in the abdomen. The question whether EBV might be involved in a certain proportion of the cases examined is discussed and further approaches to elucidate this problem are suggested.
测定了非霍奇金淋巴瘤（NHL）患儿针对爱泼斯坦-巴尔病毒（EBV）抗原的抗体滴度。针对病毒衣壳抗原（VCA）和早期抗原（EA）的IgG抗体滴度超过了健康对照受试者。另一方面，针对EBV核抗原（EBNA复合物）的抗体滴度通常低于对照组。在患者组中观察到的最显著现象是潜伏病毒感染的频繁激活，这表现为抗EA和IgM类抗VCA抗体的周期性出现。病情进展的患者中针对EBV抗原的抗体滴度通常低于病情进展较有利的患者。基于血清学发现，在伯基特型组织学的淋巴母细胞淋巴瘤、低分化淋巴细胞淋巴瘤以及腹部淋巴瘤中检测到与EBV的关系最为密切。文中讨论了EBV是否可能与一定比例的所检查病例有关的问题，并提出了进一步阐明该问题的方法。
