Naveau S, Delfraissy J F, Poitrine A, Poynard T, Chaput J C
Gastroenterol Clin Biol. 1985 Feb;9(2):109-12.
The simultaneous detection of IgM antibodies to hepatitis A virus (anti-HAV IgM) and IgM antibodies to viral capsid antigen (anti-VCA IgM) of Epstein-Barr virus (EBV) in patients with acute viral hepatitis has led us to systematically study serological markers of EBV in patients with anti-HAV IgM positive acute hepatitis and to test for anti-HAV IgM in sera of patients with acute hepatitis associated with serological evidence of current primary EBV infection. All patients studied were HBsAg negative and were not drug-addicts, nor homosexuals. In 15 consecutive patients with anti-HAV IgM positive acute hepatitis, anti-HAV IgM and anti-VCA EBV IgM antibodies were simultaneously detected in 9 cases. Of these 9 patients, antibodies to nuclear antigen were positive in 8 cases, antibodies to early antigen were positive in 7 cases and rheumatoid factor was positive in 4 cases. In 5 consecutive patients with acute hepatitis associated with serological evidence of current primary EBV infection, anti-HAV IgM was not detected. Simultaneous presence of anti-VCA EBV IgM, early antigen IgG antibodies and nuclear antigen antibodies in 7 patients with acute hepatitis associated with anti-HAV IgM suggests reactivation of EBV or reactivation of clones secreting antibodies anti-EBV in HAV infections. Furthermore, these results show that anti-VCA IgM only cannot be considered to be a specific marker of early EBV infection in patients with acute hepatitis.
在急性病毒性肝炎患者中同时检测甲型肝炎病毒IgM抗体（抗-HAV IgM）和EB病毒（EBV）的病毒衣壳抗原IgM抗体（抗-VCA IgM），促使我们系统地研究抗-HAV IgM阳性急性肝炎患者中EBV的血清学标志物，并检测当前有原发性EBV感染血清学证据的急性肝炎患者血清中的抗-HAV IgM。所有研究患者HBsAg均为阴性，且非吸毒者和同性恋者。在15例连续的抗-HAV IgM阳性急性肝炎患者中，9例同时检测到抗-HAV IgM和抗-VCA EBV IgM抗体。在这9例患者中，8例核抗原抗体阳性，7例早期抗原抗体阳性，4例类风湿因子阳性。在5例连续的有当前原发性EBV感染血清学证据的急性肝炎患者中，未检测到抗-HAV IgM。7例与抗-HAV IgM相关的急性肝炎患者同时存在抗-VCA EBV IgM、早期抗原IgG抗体和核抗原抗体，提示EBV再激活或在甲型肝炎病毒感染中分泌抗-EBV抗体的克隆再激活。此外，这些结果表明，在急性肝炎患者中，仅抗-VCA IgM不能被视为早期EBV感染的特异性标志物。
