Wu Chen-Yan, Huo Jian-Ping, Zhang Xin-Ke, Zhang Yi-Jun, Hu Wan-Ming, Yang Ping, Lu Jia-Bin, Zhang Zhi-Ling, Cao Yun
State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center.
Department of Pathology, Sun Yat-sen University Cancer Center.
Jpn J Clin Oncol. 2017 Dec 1;47(12):1182-1188. doi: 10.1093/jjco/hyx139.
To explore the role of CD15 expression in the prognosis of clear cell renal cell carcinoma (ccRCC) in Chinese patients.
The study included 301 patients who had undergone surgery for localized ccRCC. All paraffin-embedded tumor sections were collected to make a set of tissue microarrays. CD15 expression was assessed by immunohistochemistry. The relationship between CD15 expression and survival parameters, clinicopathology features was assessed. Kaplan-Meier and Cox proportional hazards model were utilized to determine the correlation between CD15 expression and overall survival (OS).
The median follow-up time was 54.6 months (range, 3-121 months). The positive rate of CD15 expression was 81.7% (246/301). The cut-off value of CD15 expression was defined as the maximum for Youden index by plotting the receiver operating characteristic curve for survival status. As the threshold was 0.5, all cases were divided into two groups: positive expression group and negative expression group. In correlation analysis, loss of CD15 expression was correlated with female gender, higher Fuhrman nuclear grade, with sarcomatoid differentiation, with necrosis, and with vascular invasion. Kaplan-Meier analysis indicated that the OS time of patients with loss of CD15 expression was shorter than that of patients with positive CD15 expression (P = 0.013).
CD15 is a significant prognostic factor in clear cell renal cell carcinoma.
探讨CD15表达在中国透明细胞肾细胞癌（ccRCC）患者预后中的作用。
该研究纳入301例接受局限性ccRCC手术的患者。收集所有石蜡包埋的肿瘤切片制作一组组织芯片。采用免疫组织化学法评估CD15表达。评估CD15表达与生存参数、临床病理特征之间的关系。利用Kaplan-Meier法和Cox比例风险模型确定CD15表达与总生存期（OS）之间的相关性。
中位随访时间为54.6个月（范围3 - 121个月）。CD15表达阳性率为81.7%（246/301）。通过绘制生存状态的受试者工作特征曲线，将CD15表达的截断值定义为约登指数的最大值。由于阈值为0.5，所有病例分为两组：阳性表达组和阴性表达组。在相关性分析中，CD15表达缺失与女性性别、较高的Fuhrman核分级、肉瘤样分化、坏死及血管侵犯相关。Kaplan-Meier分析表明，CD15表达缺失患者的OS时间短于CD15表达阳性患者（P = 0.013）。
CD15是透明细胞肾细胞癌的一个重要预后因素。
