对一个大型脆性X综合征家系的连锁研究。
Linkage studies in a large fragile X family.
作者信息
Patterson M, Bell M, Kress W, Davies K E, Froster-Iskenius U
机构信息
Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Oxford, England.
出版信息
Am J Hum Genet. 1988 Nov;43(5):684-8.
We have analyzed the segregation of five loci in the region Xq27/28 in a large family affected by the fragile X syndrome. The marker DXS115 (767) is shown to be polymorphic with the enzyme PstI, as well as with BstXI. This marker will be useful in the analysis of both fragile X and haemophilia A families. The data presented here are consistent with the following order of loci: Xcen-F9-DXS105(cX55.7,55E)-DXS98(4D-8)- FRAXA-DXS52(St14)-DXS115(767)-qter.
我们分析了一个受脆性X综合征影响的大家庭中Xq27/28区域五个基因座的分离情况。标记DXS115(767)被证明与PstI酶以及BstXI酶均呈多态性。该标记对于脆性X家族和甲型血友病家族的分析都将有用。此处呈现的数据与以下基因座顺序一致：Xcen-F9-DXS105(cX55.7,55E)-DXS98(4D-8)-FRAXA-DXS52(St14)-DXS115(767)-qter。
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