Connell Matthew T, Sjaarda Lindsey A, Radin Rose G, Kuhr Daniel, Mumford Sunni L, Plowden Torie C, Silver Robert M, Schisterman Enrique F
Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.
Program of Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.
Semin Reprod Med. 2017 Jul;35(4):344-352. doi: 10.1055/s-0037-1606384. Epub 2017 Oct 16.
Human reproduction is an inefficient process. There are several drivers of complications along the path to and during pregnancy, one of which is inflammation. Treatments to mitigate the deleterious effects of aberrant inflammation with something inexpensive and widely available like aspirin could have dramatic global impact. The Effects of Aspirin in Gestation and Reproduction (EAGeR) trial enrolled women aged 18 to 40 years with one to two prior pregnancy losses and no diagnosis of infertility. Patients were randomized to either low-dose aspirin or placebo. Here, we review the collective findings of the EAGeR trial to date and discuss several important lessons learned from the unique data resulting from this groundbreaking trial. Findings reported from this trial provide significant advances in the understanding of aspirin’s potential mechanisms in modulating reproductive processes and the role of inflammation in these processes. This review describes the collective findings of the EAGeR trial in the context of the existing literature regarding aspirin and inflammation in reproduction to inform relevant next steps in fertility and obstetric research, as well as potential implications for clinical care.
人类生殖是一个效率低下的过程。在怀孕前及怀孕期间，有多种导致并发症的因素，其中之一是炎症。用阿司匹林这种价格低廉且广泛可得的药物来减轻异常炎症的有害影响，可能会对全球产生巨大影响。妊娠与生殖中阿司匹林的作用（EAGeR）试验招募了年龄在18至40岁之间、有一到两次既往流产史且未被诊断为不孕症的女性。患者被随机分为低剂量阿司匹林组或安慰剂组。在此，我们回顾了迄今为止EAGeR试验的总体结果，并讨论了从这项开创性试验产生的独特数据中学到的几个重要经验教训。该试验报告的结果在理解阿司匹林调节生殖过程的潜在机制以及炎症在这些过程中的作用方面取得了重大进展。本综述在现有关于阿司匹林与生殖炎症的文献背景下描述了EAGeR试验的总体结果，以为生育和产科研究的相关后续步骤以及对临床护理的潜在影响提供参考。
