Mazdeh Mehrdokht, Rahimi Mahnoosh, Eftekharian Mohammad Mahdi, Omrani Mir Davood, Sayad Arezou, Taheri Mohammad, Ghafouri-Fard Soudeh
Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
Department of Neurology, Hamadan University of Medical Sciences, Hamadan, Iran.
Hum Antibodies. 2017;26(3):113-119. doi: 10.3233/HAB-170328.
Multiple sclerosis (MS) is a complex immune-related disorder of the central nervous system (CNS) in which dysregulation of different classes of T cells are involved. Variants in Ecotropic Viral Integration Site 5 (EVI5) gene has been shown to be significantly associated with MS in different populations.
However, there is no data regarding relative expression of this gene in peripheral blood of MS patients compared with healthy controls.
In the present study we assessed expression of EVI5 in 50 Iranian MS patients compared with healthy subjects by means of quantitative real time RT-PCR.
Statistical analyses showed no significant difference in EVI5 relative expression neither between total MS patients and healthy controls nor between age- and sex-based subgroups of patients and controls except for a trend toward significance in patients aged between 30 and 40 years compared with healthy subjects in both sexes (P= 0.068 and 0.075 for males and females respectively). No significant correlation was found between the expression level of this gene and disease duration, age at onset or Expanded Disability Status Scale (EDSS).
Future studies are needed to explore the role of EVI5 in the pathogenesis of MS.
多发性硬化症（MS）是一种与免疫相关的复杂中枢神经系统（CNS）疾病，涉及不同类型T细胞的失调。嗜亲性病毒整合位点5（EVI5）基因的变异已被证明在不同人群中与MS显著相关。
然而，与健康对照相比，关于该基因在MS患者外周血中的相对表达情况尚无数据。
在本研究中，我们通过定量实时RT-PCR评估了50例伊朗MS患者与健康受试者中EVI5的表达。
统计分析显示，EVI5相对表达在总MS患者与健康对照之间，以及患者和对照的年龄及性别亚组之间均无显著差异，但30至40岁患者与两性健康受试者相比有显著差异趋势（男性和女性的P值分别为0.068和0.075）。该基因的表达水平与疾病持续时间、发病年龄或扩展残疾状态量表（EDSS）之间未发现显著相关性。
未来需要进一步研究来探索EVI5在MS发病机制中的作用。
