Choi Y S, Sugano M
Laboratory of Nutrition Chemistry, Kyushu University School of Agriculture, Fukuoka, Japan.
Ann Nutr Metab. 1988;32(3):169-76. doi: 10.1159/000177430.
The effect of age on lipid metabolism was studied in rats fed diets containing safflower oil (SFO, 78% linoleic acid), evening primrose oil (EPO, 9.4% gamma-linolenic acid and 70% linoleic acid) or the mixture of safflower and linseed oil (SLO, 10.2% alpha-linolenic acid and 68% linoleic acid). The activity of hepatic HMG-CoA reductase declined with age in all groups. In adult rats, the reductase activity was high in the EPO group and low in the SLO group. The activity of hepatic cholesterol 7 alpha-hydroxylase was independent of the diet or age. Hepatic delta 6-desaturase activity was low in adult rats fed EPO. In liver microsomal phospholipids, the percentage of 22:5 n-6 decreased while that of 22:6 n-3 increased with age. The ratio of linoleate metabolites to linoleate was high in the EPO group and low in the SLO group. Liver and serum cholesterol increased with age only in rats fed the SLO diet. Thus, the results indicated an enhanced susceptibility to dietary fats with age.
研究了年龄对喂食含红花油（SFO，78%亚油酸）、月见草油（EPO，9.4%γ-亚麻酸和70%亚油酸）或红花与亚麻籽油混合物（SLO，10.2%α-亚麻酸和68%亚油酸）日粮的大鼠脂质代谢的影响。所有组中，肝脏HMG-CoA还原酶的活性均随年龄增长而下降。在成年大鼠中，EPO组的还原酶活性较高，而SLO组的还原酶活性较低。肝脏胆固醇7α-羟化酶的活性与日粮或年龄无关。喂食EPO的成年大鼠肝脏δ6-去饱和酶活性较低。在肝脏微粒体磷脂中，22:5 n-6的百分比随年龄增长而降低，而22:6 n-3的百分比随年龄增长而增加。EPO组中亚油酸代谢产物与亚油酸的比例较高，而SLO组较低。仅在喂食SLO日粮的大鼠中，肝脏和血清胆固醇随年龄增长而升高。因此，结果表明随着年龄增长，对膳食脂肪的易感性增强。
