Singh Manish Kumar, Sharma Bechan, Tiwari Pramod K
Department of Zoology, Banaras Hindu University, Varanasi 221005, India.
Department of Biochemistry, University of Allahabad, Allahabad 211002, India.
J Therm Biol. 2017 Oct;69:149-154. doi: 10.1016/j.jtherbio.2017.06.004. Epub 2017 Jun 7.
Heat shock proteins are important for maintaining protein homeostasis and cell survival. Among different classes of highly conserved Hsps, low molecular weight Hsps (sHsps) have significant place, particularly Hsp27, whose role has been demonstrated in wide range of biological processes, including development, immunity, diseases and therapy. In this review, the structure and functions of Hsp27 and related genes, their role in different cellular processes as well as in stress tolerance, is highlighted.
热休克蛋白对于维持蛋白质稳态和细胞存活至关重要。在不同种类高度保守的热休克蛋白中，低分子量热休克蛋白（小热休克蛋白）占有重要地位，尤其是热休克蛋白27（Hsp27），其作用已在包括发育、免疫、疾病和治疗在内的广泛生物学过程中得到证实。在这篇综述中，重点介绍了Hsp27及其相关基因的结构与功能、它们在不同细胞过程以及应激耐受性中的作用。
