Arrigo André-Patrick
Laboratoire Stress Oxydant, Chaperons et Apoptose, CNRS UMR 5534, Centre de Génétique Moléculaire et Cellulaire, Université Claude Bernard, 16 rue Dubois, 69622 Villeurbanne Cedex, France.
Adv Exp Med Biol. 2007;594:14-26. doi: 10.1007/978-0-387-39975-1_2.
Cells possess effective mechanisms to cope with chronic or acute disturbance of homeostasis. Key roles in maintaining or restoring homeostasis are played by the various heat shock or stress proteins (Hsps). Among the Hsps, the group of proteins characterized by low molecular masses (between 20 to 30 kDa) and homology to alpha-crystallin are called small stress proteins (denoted sHsps). The present chapter summarizes the actual knowledge of the protective mechanisms generated by the expression of mammalian Hsp27 (also denoted HspB1 in human) against the cytotoxicity induced by heat shock and oxidative stress. It also describes the anti-apoptotic properties of Hsp27 and their putative consequences in different pathological conditions.
细胞拥有应对内环境稳态慢性或急性紊乱的有效机制。各种热休克蛋白或应激蛋白（Hsps）在维持或恢复内环境稳态中发挥着关键作用。在热休克蛋白中，一组分子量较低（20至30 kDa之间）且与α-晶状体蛋白具有同源性的蛋白质被称为小应激蛋白（表示为sHsps）。本章总结了关于哺乳动物Hsp27（在人类中也表示为HspB1）表达所产生的针对热休克和氧化应激诱导的细胞毒性的保护机制的现有知识。它还描述了Hsp27的抗凋亡特性及其在不同病理条件下的可能后果。
