Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Carrera 24 No. 63-C-69, Bogotá, Colombia.
Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Carrera 24 No. 63-C-69, Bogotá, Colombia.
Autoimmun Rev. 2017 Apr;16(4):327-334. doi: 10.1016/j.autrev.2017.02.002. Epub 2017 Feb 13.
Autoimmune diseases share common immunopathogenic mechanisms (i.e., the autoimmune tautology), which explain the clinical similarities among them as well as their familial clustering. Guillain-Barré syndrome (GBS), an autoimmune peripheral neuropathy, has been recently associated with Zika virus (ZIKV) infection. Based on a series of cases, this review article provides a comparative analysis of GBS associated with ZIKV infection, contrasted with the general characteristics of GBS in light of the autoimmune tautology, including gender differences in prevalence, subphenotypes, polyautoimmunity, familial autoimmunity, age at onset, pathophysiology, ecology, genetics, ancestry, and treatment.
自身免疫性疾病具有共同的免疫发病机制（即自身免疫同义反复），这可以解释它们之间的临床相似性以及家族聚集性。吉兰-巴雷综合征（GBS）是一种自身免疫性周围神经病，最近与寨卡病毒（ZIKV）感染有关。基于一系列病例，本文通过自身免疫同义反复，对 ZIKV 感染相关 GBS 进行了对比分析，包括流行率的性别差异、亚表型、多自身免疫、家族自身免疫、发病年龄、发病机制、生态学、遗传学、祖源和治疗等方面，与 GBS 的一般特征进行了对比。
