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结节性肺淀粉样变性:一种与恶性肿瘤相关的复杂疾病。

Nodular pulmonary amyloidosis: a complex disease with malignancy association.

作者信息

Core Jacob M, Alsaad Ali A, Jiang Liuyan, Patel Neal M

机构信息

Internal Medicine, Mayo Clinic Hospital Jacksonville, Jacksonville, Florida, USA.

Internal Medicine, Mayo Clinic Florida, Jacksonville, Florida, USA.

出版信息

BMJ Case Rep. 2017 Oct 15;2017:bcr-2017-220428. doi: 10.1136/bcr-2017-220428.

Abstract

Pulmonary amyloidosis is a rare disease that incorporates deposition of amyloid microfibril material in the lung parenchyma. The condition generally presents as an indolent subacute-to-chronic pulmonary disease and requires tissue biopsy to establish the diagnosis. Nodular pulmonary amyloidosis, a subtype of pulmonary amyloidosis, is characterised by special radiographic and pathological features. While the disease can be associated with inflammatory conditions; its association with mucosal-associated lymphoid tissue (MALT lymphoma) is unusual and carries management challenges. Herein, we illustrate a case study of nodular pulmonary amyloidosis associated with underlying MALT lymphoma in a patient with known systemic lupus erythematosus. The aim of this article is to share the management experience of this complex condition with the medical community and to conduct an up-to-date literature review on nodular pulmonary amyloidosis.

摘要

肺淀粉样变性是一种罕见疾病,其特征为淀粉样微纤维物质在肺实质中沉积。该病通常表现为一种隐匿的亚急性至慢性肺部疾病,需要进行组织活检以确诊。结节性肺淀粉样变性是肺淀粉样变性的一种亚型,具有特殊的影像学和病理学特征。虽然该疾病可能与炎症性疾病相关,但其与黏膜相关淋巴组织(MALT)淋巴瘤的关联并不常见,且在治疗上具有挑战性。在此,我们阐述了一例已知患有系统性红斑狼疮的患者发生结节性肺淀粉样变性并伴有潜在MALT淋巴瘤的病例研究。本文旨在与医学界分享这种复杂疾病的治疗经验,并对结节性肺淀粉样变性进行最新的文献综述。

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