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在新加坡阴沟肠杆菌复合体分离株中，利用 Xer 重组机制携带 - 型碳青霉烯酶基因的假定整合移动元件。

Putative Integrative Mobile Elements That Exploit the Xer Recombination Machinery Carrying -Type Carbapenemase Genes in Enterobacter cloacae Complex Isolates in Singapore.

机构信息

Department of Microbiology, Singapore General Hospital, Singapore

Department of Microbiology, Singapore General Hospital, Singapore.

出版信息

Antimicrob Agents Chemother. 2017 Dec 21;62(1). doi: 10.1128/AAC.01542-17. Print 2018 Jan.

DOI:10.1128/AAC.01542-17
PMID:29038281
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5740307/
Abstract

Whole-genome sequencing was performed on 16 isolates of the carbapenemase-producing complex to determine the flanking regions of -type genes. Phylogenetic analysis of multilocus sequence typing (MLST) targets separated the isolates into 4 clusters. The -type genes were all found on Xer-dependent integrative mobile elements (IMEX). The IMEX elements of 5 isolates were similar to those described in Canada, while the remainder were novel. Five isolates had IMEX elements lacking a resolvase and recombinase.

摘要

对 16 株产碳青霉烯酶复合体的分离株进行了全基因组测序，以确定 -型基因的侧翼区域。多位点序列分型（MLST）靶标的系统发育分析将分离株分为 4 个聚类。-型基因均位于 Xer 依赖型整合移动元件（IMEX）上。5 株分离株的 IMEX 元件与在加拿大描述的元件相似，其余的则是新的。5 株分离株的 IMEX 元件缺乏内切酶和重组酶。

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本文引用的文献

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Enterobacter cloacae Complex Isolates Harboring or -Type Class A Carbapenemase Genes on Novel Chromosomal Integrative Elements and Plasmids.阴沟肠杆菌复合体分离株在新型染色体整合元件和质粒上携带OXA或KPC型A类碳青霉烯酶基因。
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2
Characterization of a Novel Putative Xer-Dependent Integrative Mobile Element Carrying the bla(NMC-A) Carbapenemase Gene, Inserted into the Chromosome of Members of the Enterobacter cloacae Complex.一种携带bla(NMC-A)碳青霉烯酶基因的新型假定Xer依赖性整合移动元件的特性分析，该元件插入阴沟肠杆菌复合体成员的染色体中。
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