Celano Marilena, Rosignolo Francesca, Maggisano Valentina, Pecce Valeria, Iannone Michelangelo, Russo Diego, Bulotta Stefania
Department of Health Sciences, Magna Graecia University of Catanzaro, 88100 Catanzaro, Italy.
Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, 00161 Rome, Italy.
Int J Genomics. 2017;2017:6496570. doi: 10.1155/2017/6496570. Epub 2017 Sep 6.
Optimal management of patients with thyroid cancer requires the use of sensitive and specific biomarkers. For early diagnosis and effective follow-up, the currently available cytological and serum biomarkers, thyroglobulin and calcitonin, present severe limitations. Research on microRNA expression in thyroid tumors is providing new insights for the development of novel biomarkers that can be used to diagnose thyroid cancer and optimize its management. In this review, we will examine some of the methods commonly used to detect and quantify microRNA in biospecimens from patients with thyroid tumor, as well as the potential applications of these techniques for developing microRNA-based biomarkers for the diagnosis and prognostic evaluation of thyroid cancers.
甲状腺癌患者的最佳管理需要使用敏感且特异的生物标志物。对于早期诊断和有效的随访，目前可用的细胞学和血清生物标志物，即甲状腺球蛋白和降钙素，存在严重局限性。对甲状腺肿瘤中微小RNA表达的研究为新型生物标志物的开发提供了新见解，这些生物标志物可用于诊断甲状腺癌并优化其管理。在本综述中，我们将研究一些常用于检测和定量甲状腺肿瘤患者生物样本中微小RNA的方法，以及这些技术在开发基于微小RNA的生物标志物用于甲状腺癌诊断和预后评估方面的潜在应用。
