Vahed Y A, Koeslag J H, J de V Lochner J
Department of Physiology, University of Cape Town Medical School, South Africa.
J Endocrinol. 1988 Oct;119(1):167-71. doi: 10.1677/joe.0.1190167.
Post-exercise ketosis is not abolished by glucose ingestion immediately after exercise but is counteracted by simultaneous beta-adrenergic blockade. To investigate the effect of beta-adrenergic blockade on post-exercise ketosis without the ingestion of glucose, we administered propranolol (1 mg/kg body mass) to 15 carbohydrate-starved people, of whom five had just walked 9 km in 2 h. There were 43 control subjects (no propranolol). The blood concentration of 3-hydroxybutyrate rose from 0.18 +/- 0.02 (S.E.M.) mmol/l at 07.00 h to 0.35 +/- 0.04 mmol/l at 09.00 h whether the subjects had exercised during those 2 h or not (d.f. = 57). The blood concentration of 3-hydroxybutyrate at 15.00 h in the groups not treated with propranolol was not affected by exercise (0.95 +/- 0.90 mmol/l; d.f. = 42). Propranolol significantly raised the concentration of 3-hydroxybutyrate at 15.00 h to 1.68 +/- 0.26 mmol/l when given after exercise (d.f. = 4), but lowered it to 0.46 +/- 0.07 mmol/l in the non-exercised group (d.f. = 9). This was not accompanied by significant differences in the blood concentrations of glucose, free fatty acid, insulin or glucagon. The difference in response to propranolol administration is probably determined by the alanine and lactate flux from muscle for hepatic oxaloacetate synthesis.
运动后立即摄入葡萄糖并不能消除运动后酮症，但同时进行β-肾上腺素能阻滞可对其产生抵消作用。为了研究在不摄入葡萄糖的情况下β-肾上腺素能阻滞对运动后酮症的影响，我们对15名碳水化合物缺乏的人给予了普萘洛尔（1毫克/千克体重），其中5人在2小时内刚刚步行了9公里。有43名对照受试者（未使用普萘洛尔）。无论受试者在这2小时内是否运动，3-羟基丁酸的血浓度从07:00时的0.18±0.02（标准误）毫摩尔/升升至09:00时的0.35±0.04毫摩尔/升（自由度=57）。未用普萘洛尔治疗的组在15:00时的3-羟基丁酸血浓度不受运动影响（0.95±0.90毫摩尔/升；自由度=42）。运动后给予普萘洛尔时，15:00时3-羟基丁酸的浓度显著升高至1.68±0.26毫摩尔/升（自由度=4），但在未运动组中降至0.46±0.07毫摩尔/升（自由度=9）。这并未伴随血糖、游离脂肪酸、胰岛素或胰高血糖素血浓度的显著差异。对普萘洛尔给药反应的差异可能由肌肉中用于肝脏草酰乙酸合成的丙氨酸和乳酸通量决定。
