Adams J H, Koeslag J H
Department of Physiology, University of Cape Town Medical School, Observatory, South Africa.
Eur J Appl Physiol Occup Physiol. 1989;59(3):189-94. doi: 10.1007/BF02386186.
Post-exercise ketosis is known to be suppressed by physical training and by a high carbohydrate diet. As a result it has often been presumed, but not proven, that the development of post-exercise ketosis is closely related to the glycogen content of the liver. We therefore studied the effect of 1 h of treadmill running on the blood 3-hydroxybutyrate and liver and muscle glycogen concentrations of carbohydrate-loaded trained (n = 72) and untrained rats (n = 72). Resting liver and muscle glycogen levels were 25%-30% higher in the trained than in the untrained animals. The resting 3-hydroxybutyrate concentrations of both groups of rats were very low: less than 0.08 mmol.l-1. Exercise did not significantly influence the blood 3-hydroxybutyrate concentrations of trained rats, but caused a marked post-exercise ketosis (1.40 +/- 0.40 mmol.l-1 h after exercise) in the untrained animals, the time-course of which was the approximate inverse of the changes in liver glycogen concentration. Interpreting the results in the light of similar data obtained after a normal and low carbohydrate diet it has been concluded that trained animals probably owe their relative resistance to post-exercise ketosis to their higher liver glycogen concentrations as well as to greater peripheral stores of mobilizable carbohydrate.
已知运动后酮症会受到体育锻炼和高碳水化合物饮食的抑制。因此，人们常常推测（但未得到证实）运动后酮症的发生与肝脏糖原含量密切相关。于是，我们研究了1小时跑步机跑步对碳水化合物负荷充足的训练大鼠（n = 72）和未训练大鼠（n = 72）的血液3-羟基丁酸以及肝脏和肌肉糖原浓度的影响。训练大鼠的静息肝脏和肌肉糖原水平比未训练动物高25%-30%。两组大鼠的静息3-羟基丁酸浓度都非常低：低于0.08 mmol·l-1。运动对训练大鼠的血液3-羟基丁酸浓度没有显著影响，但在未训练的动物中导致了明显的运动后酮症（运动后1小时为1.40±0.40 mmol·l-1），其时间进程与肝脏糖原浓度的变化大致相反。根据在正常和低碳水化合物饮食后获得的类似数据来解释这些结果，得出的结论是，训练有素的动物对运动后酮症的相对抵抗力可能归因于其较高的肝脏糖原浓度以及更多可动员碳水化合物的外周储存。
