Metafora S, Peluso G, Ravagnan G, Marchese M, Di Pietro M, Mancini A, Panza N, Fusco A, Porta R
CNR Institute of Protein Biochemistry and Enzymology, Naples, Italy.
Med Oncol Tumor Pharmacother. 1988;5(4):223-31. doi: 10.1007/BF03003188.
Transglutaminase (TGase) activity was reduced in intact mitogen-stimulated human peripheral blood lymphocytes (PBL) when compared to intact resting PBL. Moreover, a treatment of the same quiescent immunocompetent cells with purified liver TGase and Ca2+ completely suppressed the mitogen-induced blast transformation. A decrease in TGase activity in neoplastically transformed seminal vesicle epithelial cells with respect to their normal parent counterpart was also observed. Our data support the notion of a possible implication of TGase in cell proliferation and transformation.
与未受刺激的完整人外周血淋巴细胞（PBL）相比，有丝分裂原刺激的完整人外周血淋巴细胞中的转谷氨酰胺酶（TGase）活性降低。此外，用纯化的肝脏TGase和Ca2+处理相同的静止免疫活性细胞，可完全抑制有丝分裂原诱导的母细胞转化。在肿瘤转化的精囊上皮细胞中，相对于其正常亲本细胞，也观察到TGase活性降低。我们的数据支持TGase可能参与细胞增殖和转化的观点。
