Department of Clinical Laboratory, Nanjing Integrated Traditional Chinese and Western Medicine Hospital Affiliated with Nanjing University of Chinese Medicine, Nanjing 210000, P.R. China.
Department of Nephrology, Children's Hospital of Nanjing Medical University, Nanjing 210000, P.R. China.
Mol Med Rep. 2017 Dec;16(6):9035-9042. doi: 10.3892/mmr.2017.7747. Epub 2017 Oct 10.
Interleukin-8 (IL-8) possesses tumorigenic and proangiogenic properties, and is overexpressed in many human cancer types. However, only few studies have demonstrated the mechanisms of action of IL‑8 regarding the ability to promote proliferation and to inhibit apoptosis in prostate cancer. Here, the aim of the present study was to investigate the effects of IL‑8 on the prostate cancer cell line and determine possible mechanisms underlying its effect. In this study, IL‑8 was shown to be significantly upregulated in prostate cancer compared with paired normal control tissues. The data showed that IL‑8 exhibits direct oncogenicity, which significantly induced cell proliferation, invasion and attenuated apoptosis in prostate cancer cells via signal transducer and activator of transcription 3/protein kinase B/nuclear factor‑κB signaling pathways. In conclusion, modulation of IL‑8 expression or its associated signaling pathway may provide a novel working mechanism of IL‑8 in prostate cancer, and a promising strategy for controlling the progression and metastasis of prostate cancer.
白细胞介素-8（IL-8）具有致瘤和促血管生成特性，在许多人类癌症类型中过度表达。然而，只有少数研究表明了 IL-8 促进前列腺癌细胞增殖和抑制细胞凋亡的作用机制。本研究旨在探讨 IL-8 对前列腺癌细胞系的影响，并确定其作用的可能机制。本研究表明，与配对的正常对照组织相比，前列腺癌中 IL-8 的表达显著上调。研究数据表明，IL-8 具有直接致癌性，通过信号转导和转录激活因子 3/蛋白激酶 B/核因子-κB 信号通路显著诱导前列腺癌细胞增殖、侵袭和减弱细胞凋亡。总之，调节 IL-8 的表达或其相关信号通路可能为 IL-8 在前列腺癌中的作用提供新的工作机制，并为控制前列腺癌的进展和转移提供有前途的策略。
