Lincoln Christie M, Fata Peter, Sotardi Susan, Pohlen Michael, Uribe Tomas, Bello Jacqueline A
1 Department of Radiology, Baylor College of Medicine , Houston, TX , USA.
2 Department of Radiology, Houston Methodist , Houston, TX , USA.
Br J Radiol. 2018 Feb;91(1082):20170553. doi: 10.1259/bjr.20170553. Epub 2017 Nov 3.
A wide range of treatment-related side effects result in specific neurologic symptoms and signs and neuroimaging features. Even to the most seasoned neuroradiologist, elucidating therapy-related side effects from other common mimics can be challenging. We provide a pictorial survey of some common and uncommon medication-induced and therapy-related neuroimaging manifestations, discuss pathophysiology and common pitfalls in imaging and diagnosis.
A case-based review is utilized to depict scenarios on a routine basis in a general radiology or neuroradiology practice such as medication-induced posterior reversible encephalopathy syndrome to the more challenging cases of pseudoprogression and pseudoregression in temozolmide and bevacizumab therapy in gliobastoma treatment protocols.
Knowledge of the treatment-induced imaging abnormalities is essential in the accurate interpretation and diagnosis from the most routine to most challenging of clinical situations. We provide a pictorial review for the radiologist to employ in order to be an invaluable provider to our clinical colleagues and patients.
多种与治疗相关的副作用会导致特定的神经症状、体征及神经影像学特征。即便对于经验最为丰富的神经放射科医生而言，区分治疗相关副作用与其他常见的类似情况也颇具挑战。我们提供了一些常见及罕见的药物所致和治疗相关神经影像学表现的图谱综述，讨论了其病理生理学以及影像学和诊断中的常见陷阱。
采用基于病例的回顾，描绘一般放射科或神经放射科日常工作中的各种情况，如药物所致的后部可逆性脑病综合征，以及胶质母细胞瘤治疗方案中替莫唑胺和贝伐单抗治疗时更具挑战性的假性进展和假性消退病例。
了解治疗引起的影像学异常对于准确解读和诊断从最常规到最具挑战性的临床情况至关重要。我们为放射科医生提供了一份图谱综述，以便他们成为对临床同事和患者极有价值的信息提供者。
