Mammadov Emil, Dervisoglu Sergulen, Elicevik Mehmet, Emir Haluk, Soylet Yunus, Buyukunal S N Cenk
Department of Pediatric Surgery, Near East University Medical Faculty, Turkey.
Department of Pathology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
Int Braz J Urol. 2017 Nov-Dec;43(6):1152-1159. doi: 10.1590/S1677-5538.IBJU.2016.0548.
To investigate the histopathologic changes in native bladder and gastrointestinal segment, the relation between histopathologic changes, type of operation and the period passed over operation in patients with bladder augmentation.
Twenty consecutive patients were enrolled in this study. Histopathologic evaluation of the cystoscopic mucosal biopsies from native bladder and enteric augment was performed in all patients.
Active or chronic non-specific inflammation of various degrees was found in all specimens except two. Metaplastic changes were detected in 3 patients. Two patients had squamous metaplasia (one focal, one extensive) and one patient had intestinal metaplasia. All metaplastic changes were found in native bladder specimens. The type of augmentation in patients with metaplastic changes were ileocystoplasty and sigmoidocystoplasty. No signs of malignancy were detected in any patient.
The complexity of the disorders requiring bladder augmentation does not let the surgeons to draw a clear line between different groups of complications including malignancy formation. However, due to challenging course of the augmentation procedure itself, surgeons should be well aware of the possibility of malignancy development.
研究膀胱扩大术患者自体膀胱和胃肠道段的组织病理学变化、组织病理学变化与手术类型及术后时间的关系。
连续纳入20例患者。对所有患者进行自体膀胱和肠道扩大部位的膀胱镜黏膜活检组织病理学评估。
除2例标本外，所有标本均发现不同程度的活动性或慢性非特异性炎症。3例患者检测到化生改变。2例患者有鳞状化生（1例局灶性，1例广泛性），1例患者有肠化生。所有化生改变均在自体膀胱标本中发现。发生化生改变的患者的扩大类型为回肠膀胱扩大术和乙状结肠膀胱扩大术。所有患者均未检测到恶性肿瘤迹象。
需要膀胱扩大术的疾病的复杂性使外科医生无法在包括恶性肿瘤形成在内的不同并发症组之间划出明确界限。然而，由于扩大手术本身的挑战性过程，外科医生应充分意识到恶性肿瘤发生的可能性。
