a School of Sport Exercise and Health Sciences , Loughborough University , Loughborough , UK.
b Institute of Mental Health , University of Nottingham , Nottingham , UK.
Aging Ment Health. 2019 Jan;23(1):15-21. doi: 10.1080/13607863.2017.1390731. Epub 2017 Oct 17.
To inform public health interventions, further investigation is needed to identify: (1) frequency/intensity of everyday physical activity (PA) needed to reduce dementia risk; (2) whether post-diagnosis reduction in PA is associated with cognitive outcomes in people with dementia.
Data from 11,391 men and women (aged ≥50) were obtained from the English Longitudinal Study of Ageing cohort. Assessments were carried out at baseline (2002-2003) and at biannual follow-ups (2004-2013).
Older adults who carried out moderate to vigorous activity at least once per week had a 34%-50% lower risk for cognitive decline and dementia over an 8-10 year follow-up period. From pre- to post-dementia diagnosis, those who decreased PA levels had a larger decrease in immediate recall scores, compared to those who maintained or increased PA levels (analyses were adjusted for changes in physical function).
PA was associated with cognitive outcomes in a dose-dependent manner. Reduction in PA after diagnosis was associated with accelerated cognitive decline and maintaining PA may reduce symptom progression in dementia.
为了制定公共卫生干预措施，需要进一步调查以确定：（1）降低痴呆风险所需的日常体力活动（PA）的频率/强度；（2）在诊断后减少 PA 是否与痴呆患者的认知结果相关。
数据来自英国老龄化纵向研究队列中的 11391 名男性和女性（年龄≥50 岁）。在基线（2002-2003 年）和每两年一次的随访（2004-2013 年）进行评估。
在 8-10 年的随访期间，每周至少进行一次中等到剧烈活动的老年人患认知能力下降和痴呆的风险降低 34%-50%。与保持或增加 PA 水平的人相比，那些减少 PA 水平的人在即时回忆测试中的分数下降更大（分析调整了身体功能的变化）。
PA 与认知结果呈剂量依赖性相关。诊断后 PA 的减少与认知衰退加速有关，而保持 PA 可能会减缓痴呆症的症状进展。
