Brown Karl, Shutes-David Andrew, Payne Sarah, Jankowski Adrienne, Wilson Katie, Seto Edmund, Tsuang Debby W
Geriatric Research, Education, and Clinical Center, VISN-20, VA Puget Sound Health Care System, Seattle, WA, USA.
Mental Illness Research, Education, and Clinical Center, VISN-20, VA Puget Sound Health Care System, Seattle, WA, USA.
Digit Health. 2025 Apr 3;11:20552076251330808. doi: 10.1177/20552076251330808. eCollection 2025 Jan-Dec.
This study sought to investigate differences in physical activity and activity fragmentation between older adults with and without dementia and between older adults with dementia with Lewy bodies (DLB) and older adults with Alzheimer's disease (AD). The study also sought to investigate how these differences vary in magnitude at different ages.
Accelerometry data were analyzed from individuals with dementia ( = 94) and individuals without dementia ( = 613) who participated in the National Health and Aging Trends Study (NHATS), as well as from individuals with DLB ( = 12) and AD ( = 10) who participated in a pilot study.
In the NHATS cohort, individuals without dementia had more activity counts (0.325 million [95% CI 0.162 million, 0.487 million]) and a longer active bout length (0.631 minutes [95% CI 0.311, 0.952]) at the mean age of 79 than individuals with dementia at the same age. There was also suggestive evidence that individuals without dementia had a shorter resting bout length (-2.196 minutes [95% CI -4.996, 0.605]) than individuals with dementia. Differences in data collection and processing prevented direct comparisons between the cohorts, and the parallel analyses in the smaller cohort were underpowered to detect statistically significant differences between DLB and AD.
This work shows that objectively measured accelerometry data differ between individuals with and without dementia; future studies with larger samples should investigate whether accelerometry data can be used to aid in the early identification of dementia and differentiation of dementia subtypes.
本研究旨在调查患有和未患有痴呆症的老年人之间，以及患有路易体痴呆（DLB）的老年人和患有阿尔茨海默病（AD）的老年人之间身体活动及活动碎片化的差异。该研究还试图调查这些差异在不同年龄阶段的变化程度。
分析了参与国家健康与老龄化趋势研究（NHATS）的患有痴呆症的个体（n = 94）和未患有痴呆症的个体（n = 613）的加速度计数据，以及参与一项试点研究的患有DLB的个体（n = 12）和患有AD的个体（n = 10）的加速度计数据。
在NHATS队列中，在平均年龄为79岁时，未患痴呆症的个体比同年龄患痴呆症的个体有更多的活动计数（32.5万次[95%可信区间16.2万次，48.7万次]）和更长的活动时长（0.631分钟[95%可信区间0.311，0.952]）。也有提示性证据表明，未患痴呆症的个体的静息时长比患痴呆症的个体短（-2.196分钟[95%可信区间-4.996，0.605]）。数据收集和处理方面的差异阻碍了队列之间的直接比较，并且在较小队列中的平行分析检测DLB和AD之间统计学显著差异的能力不足。
这项研究表明，通过客观测量的加速度计数据在患有和未患有痴呆症的个体之间存在差异；未来更大样本量的研究应调查加速度计数据是否可用于帮助早期识别痴呆症以及区分痴呆症亚型。
