O'Doherty M J, Thomas S, Page C, Barlow D, Bradbeer C, Nunan T O, Bateman N T
Department of Nuclear Medicine, St. Thomas' Hospital, London.
Lancet. 1988 Dec 3;2(8623):1283-6. doi: 10.1016/s0140-6736(88)92894-2.
The study compared the pulmonary deposition of nebulised pentamidine when inhaled by way of different nebuliser systems by nine human-immunodeficiency-virus-positive patients with a history of previous Pneumocystis carinii pneumonia. Pentamidine, 50 mg or 300 mg, mixed with technetium-99m-labelled human serum albumin in a total volume of 3 ml, was administered by way of three jet nebulisers (System 22', 'System 22 Mizer', and 'Respigard II') operated with a gas flow of 6 l/min, and one ultrasound nebuliser ('Pulmosonic'). Pulmonary and non-pulmonary isotope deposition was measured for each apparatus and adverse effects and lung function tests were recorded. For both doses of pentamidine, the system 22 mizer produced the largest pulmonary isotope deposition and it was completed in the shortest time. Oropharyngeal and gastric deposition were least with the respigard II, which also caused the fewest adverse effects. The adverse effects were greatest with the system 22 mizer and pulmosonic and the higher pentamidine dose, which also caused significant reductions in measurements of pulmonary function. It is concluded that either the system 22 mizer or the respigard II should be used to administer nebulised pentamidine.
该研究比较了9例有卡氏肺孢子虫肺炎病史的人类免疫缺陷病毒阳性患者通过不同雾化器系统吸入戊烷脒时的肺部沉积情况。将50毫克或300毫克戊烷脒与99m锝标记的人血清白蛋白混合，总体积为3毫升，通过3种气流为6升/分钟的喷射雾化器（“22型系统”、“22型米泽系统”和“Respigard II”）以及1种超声雾化器（“Pulmosonic”）给药。测量了每种仪器的肺部和非肺部同位素沉积情况，并记录了不良反应和肺功能测试结果。对于两种剂量的戊烷脒，22型米泽系统产生的肺部同位素沉积量最大，且完成时间最短。Respigard II的口咽和胃部沉积最少，其引起的不良反应也最少。22型米泽系统和Pulmosonic以及较高剂量的戊烷脒引起的不良反应最大，这也导致肺功能测量值显著降低。结论是应使用22型米泽系统或Respigard II来雾化吸入戊烷脒。
