Bio-information Lab, University of Tokyo.
University of Warsaw, Center of New Technologies (CeNT), Warsaw, Poland.
Brief Funct Genomics. 2018 Nov 26;17(6):402-414. doi: 10.1093/bfgp/elx028.
In one more years, we will 'celebrate' an exact centenary of the Spanish flu pandemic. With the rapid evolution of the influenza virus, the possibility of novel pandemic remains ever a concern. This review covers our current knowledge of the influenza A virus: on the role of RNA in translation, replication, what is known of the expressed proteins and the protein products generated from alternative splicing, and on the role of base pairing in RNA structure. We highlight the main events associated with viral entry into the cell, the transcription and replication process, an export of the viral genetic material from the nucleus and the final release of the virus. We discuss the observed potential roles of RNA secondary structure (the RNA base-pairing arrangement) and RNA/RNA interactions in this scheme.
再过一年，我们将“庆祝”西班牙流感大流行整整一百周年。随着流感病毒的快速进化，新的大流行仍然是一个令人担忧的问题。这篇综述涵盖了我们目前对甲型流感病毒的了解：RNA 在翻译、复制中的作用，对表达蛋白的了解，以及从选择性剪接产生的蛋白产物，以及碱基配对在 RNA 结构中的作用。我们强调了与病毒进入细胞、转录和复制过程、病毒遗传物质从细胞核输出以及病毒最终释放相关的主要事件。我们讨论了在这种方案中观察到的 RNA 二级结构（RNA 碱基配对排列）和 RNA/RNA 相互作用的潜在作用。
