Department of Pure and Applied Chemistry, Faculty of Science and Technology, Tokyo University of Science, 2641- Yamazaki, Noda, Chiba, 278- 8510, Japan.
L. V. M. C. Inc. Komagome- 7- 14- 3, Toshima- ku 170- 0003, Tokyo, Japan.
Colloids Surf B Biointerfaces. 2018 Jan 1;161:59-66. doi: 10.1016/j.colsurfb.2017.10.014. Epub 2017 Oct 6.
We have studied the phase behavior of dipalmitoylphosphatidylcholine (DPPC) containing sodium β-sitosteryl sulfate (PSO). PSO was found to lower the phase transition temperature of DPPC to a higher degree than cholesterol or β-sitosterol. It also gave rise to the formation of a modulated (ripple) phase (P) at low to moderate concentrations. At concentrations greater than 25 mol%, it completely changed the membrane into a fluid phase. This shows that PSO is capable of disordering the hydrocarbon chains of PC efficiently. The characteristics of PSO for fluidizing the membrane can be useful for the pharmaceutical and cosmetics industries.
我们研究了含有β-谷甾醇硫酸钠（PSO）的二棕榈酰磷脂酰胆碱（DPPC）的相行为。PSO 比胆固醇或β-谷甾醇更能显著降低 DPPC 的相变温度。在低至中等浓度下，它还会导致形成调制（波纹）相（P）。在浓度大于 25mol%时，它会完全将膜转变为流体相。这表明 PSO 能够有效地使 PC 的烃链无序化。PSO 使膜流化的特性可能对制药和化妆品行业有用。
