Kafle Ananda, Akamatsu Masaaki, Bhadani Avinash, Sakai Kenichi, Kaise Chihiro, Kaneko Teruhisa, Sakai Hideki
Department of Pure and Applied Chemistry, Faculty of Science and Technology, Tokyo University of Science.
Research Institute for Science and Technology, Tokyo University of Science.
J Oleo Sci. 2018 Dec 1;67(12):1511-1519. doi: 10.5650/jos.ess18147. Epub 2018 Nov 15.
The effect of β-sitosteryl sulfate (PSO) on the liposomal size, stability, fluidity, and dispersibility of DPPC liposomes prepared by vortex mixing, bath-sonication, and probe-sonication has been studied. PSO significantly decreases the particle size of the multilamellar liposomes (MLVs). The sizes of the vortexmixed and the bath-sonicated liposomes vary as a function of PSO concentration. On the other hand, PSO has only little effect on the particle sizes of probe sonicated liposomes. In some cases, the liposomal stability at higher PSO concentrations depends on the preparation method. PSO improves the dispersibility of the DPPC liposomes and enhances their hydration. It also increases the fluidity of the liposomes prepared by each method. Our results suggest that liposomes consisting of DPPC and PSO can be suitable as a cosmetic or pharmaceutical ingredient for the effective delivery of the active components into the body.
研究了β-谷甾醇硫酸酯（PSO）对通过涡旋混合、浴式超声处理和探头超声处理制备的二棕榈酰磷脂酰胆碱（DPPC）脂质体的脂质体大小、稳定性、流动性和分散性的影响。PSO显著降低了多层脂质体（MLV）的粒径。涡旋混合和浴式超声处理的脂质体大小随PSO浓度而变化。另一方面，PSO对探头超声处理的脂质体粒径影响很小。在某些情况下，较高PSO浓度下脂质体的稳定性取决于制备方法。PSO改善了DPPC脂质体的分散性并增强了它们的水合作用。它还增加了通过每种方法制备的脂质体的流动性。我们的结果表明，由DPPC和PSO组成的脂质体可适合作为一种化妆品或药物成分，用于将活性成分有效递送至体内。
