Laboratoire Parole et Langage UMR 7309, Aix-Marseille Université, Marseille, France.
Service de Neurophysiologie Clinique, Centre Hospitalo Universitaire de la Timone, 264, rue Saint-Pierre, 13005 Marseille, France; Aix Marseille Univ, Inserm, INS, Institut de Neurosciences des Systèmes, Marseille, France.
Int J Psychophysiol. 2018 Jan;123:103-110. doi: 10.1016/j.ijpsycho.2017.10.005. Epub 2017 Oct 16.
This study investigates the physiological basis of effects of skin conductance biofeedback on anxiety disorders, depressive disorders and stress in drug-resistant temporal lobe epilepsy (TLE). This method presents an interest in seizure reduction and improvement in psychiatric comorbidities frequently associated with TLE. Our goal was to better understand the impact of biofeedback on seizure control and on emotional regulation. Fifteen patients with TLE were treated with 12 skin conductance biofeedback sessions and compared with 15 control TLE patients on a waiting list. They were evaluated in terms of seizure frequency, clinical evaluations of anxiety and depression and skin conductance responses (SCR) to five emotions: fear, disgust, sadness, happiness and peacefulness induced by short films. Biofeedback training significantly reduced seizure frequency with a mean reduction of -47.42% in the biofeedback group, while the control group did not differ at the two time measures. A significant improvement was found for depression and trait-anxiety in the biofeedback group but not in the control group. There were no differences on SCR on any emotion after biofeedback treatment. A correlation was found between mean change in SCR over the biofeedback treatment and the reduction of seizure frequency, but not between SCR changes and scores on psychiatric comorbidities. These results show independent effect of biofeedback on mood and seizure control. Improvements in anxiety and depressive symptoms were not related to SCR, whereas improved seizure control was, suggesting differential mechanisms underlying these two phenomena.
这项研究调查了皮肤电传导生物反馈对耐药性颞叶癫痫（TLE）患者焦虑症、抑郁症和压力的生理基础。这种方法对减少癫痫发作和改善 TLE 常伴发的精神共病具有重要意义。我们的目标是更好地理解生物反馈对癫痫发作控制和情绪调节的影响。15 名 TLE 患者接受了 12 次皮肤电传导生物反馈治疗，并与 15 名等待治疗的 TLE 对照患者进行比较。通过评估癫痫发作频率、焦虑和抑郁的临床评估以及皮肤电传导反应（SCR），来评估这两种方法。SCR 对五种情绪（恐惧、厌恶、悲伤、快乐和平静）的反应：通过短片诱发。生物反馈训练显著降低了癫痫发作频率，生物反馈组的平均降低率为-47.42%，而对照组在两个时间点上没有差异。生物反馈组的抑郁和特质焦虑显著改善，但对照组没有。生物反馈治疗后，对任何情绪的 SCR 均无差异。在生物反馈治疗过程中 SCR 的平均变化与癫痫发作频率的降低之间存在相关性，但 SCR 变化与精神共病评分之间没有相关性。这些结果表明生物反馈对情绪和癫痫发作控制有独立的影响。焦虑和抑郁症状的改善与 SCR 无关，而癫痫发作控制的改善与 SCR 有关，这表明这两种现象的潜在机制不同。
