Department of Psychiatry, Hokkaido University Graduate School of Medicine, 060-8638 West 5, North 14, North District, Sapporo City, Hokkaido, Japan.
Faculty of Computer Science and Engineering, Kyoto Sangyo University, 603-8555 Kamikamo Honzan, Kitaku, Kyoto City, Kyoto, Japan.
Epilepsy Behav. 2019 Nov;100(Pt A):106517. doi: 10.1016/j.yebeh.2019.106517. Epub 2019 Sep 28.
Biofeedback therapy using electrodermal activity (EDA) is a new noninvasive therapy for intractable epilepsy. However, the characteristics of EDA in patients with epilepsy are little known; therefore, we assessed the EDA characteristics in patients with epilepsy.
A cross-sectional observational study was conducted in 22 patients with epilepsy and 24 healthy individuals. We collected information on demographic characteristics, EDA, and state anxiety from both groups, and epilepsy diagnosis, seizure number per month, disease duration, and number of antiepileptic drugs (AED) from the epilepsy group. A wristband device was used to measure resting EDA from both wrists for 10 min under controlled temperature and humidity. We compared the EDA levels between the epilepsy group and the control group and examined correlations between EDA and epilepsy-associated factors in the epilepsy group.
A decreasing trend in EDA was observed during the first 1 min from the start of the measurement in 22 patients with epilepsy (with or without seizures) compared with healthy controls (P = 0.12). However, a significant decrease in EDA was found in 18 patients with epilepsy with seizures compared with healthy controls (-0.48 versus -0.26; P = 0.036). Furthermore, seizure frequency showed a significant inverse correlation with EDA in the epilepsy group (ρ = -0.50, P = 0.016). However, neither disease duration nor the number of drugs prescribed correlated with EDA in the epilepsy group .
Marginally decreased EDA was observed in patients with epilepsy, and significantly decreased EDA was found in patients with a higher seizure frequency. The present findings shed light on the appropriateness of EDA-biofeedback therapy in epilepsy.
使用皮肤电活动（EDA）的生物反馈疗法是一种治疗难治性癫痫的新的非侵入性疗法。然而，癫痫患者的 EDA 特征知之甚少；因此，我们评估了癫痫患者的 EDA 特征。
我们对 22 例癫痫患者和 24 例健康对照进行了一项横断面观察性研究。我们从两组中收集了人口统计学特征、EDA 和状态焦虑的信息，从癫痫组中收集了癫痫诊断、每月发作次数、疾病持续时间和抗癫痫药物（AED）数量的信息。使用腕带设备在受控温度和湿度下从两个手腕测量 10 分钟的静息 EDA。我们比较了癫痫组和对照组之间的 EDA 水平，并检查了癫痫组中 EDA 与癫痫相关因素之间的相关性。
与健康对照组相比，22 例癫痫患者（有或无发作）在测量开始后的前 1 分钟内 EDA 呈下降趋势（P=0.12）。然而，18 例有发作的癫痫患者的 EDA 明显下降，与健康对照组相比（-0.48 与-0.26；P=0.036）。此外，癫痫组中发作频率与 EDA 呈显著负相关（ρ=-0.50，P=0.016）。然而，癫痫组中疾病持续时间或所开药物数量与 EDA 均无相关性。
癫痫患者的 EDA 观察到略有降低，发作频率较高的患者的 EDA 明显降低。本研究结果为 EDA-生物反馈疗法在癫痫中的适用性提供了依据。
