National Renal Complement Therapeutics Centre, Newcastle upon Tyne, Hospitals National Health Service Foundation Trust, Newcastle upon Tyne, UK.
Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK; and.
Clin J Am Soc Nephrol. 2018 Feb 7;13(2):300-317. doi: 10.2215/CJN.00620117. Epub 2017 Oct 17.
Thrombotic microangiopathy can manifest in a diverse range of diseases and is characterized by thrombocytopenia, microangiopathic hemolytic anemia, and organ injury, including AKI. It can be associated with significant morbidity and mortality, but a systematic approach to investigation and prompt initiation of supportive management and, in some cases, effective specific treatment can result in good outcomes. This review considers the classification, pathology, epidemiology, characteristics, and pathogenesis of the thrombotic microangiopathies, and outlines a pragmatic approach to diagnosis and management.
血栓性微血管病可在多种疾病中表现出来,其特征是血小板减少症、微血管性溶血性贫血和器官损伤,包括急性肾损伤。它可能与显著的发病率和死亡率相关,但通过系统的方法进行调查,并及时开始支持性治疗,在某些情况下,进行有效的特定治疗,可带来良好的结果。本综述考虑了血栓性微血管病的分类、病理学、流行病学、特征和发病机制,并概述了一种实用的诊断和管理方法。