Significant association of the rs851797 polymorphism with clinical outcome of ovarian cancer.

BACKGROUND

Exonuclease 1 (), one of DNA mismatch repair pathway genes, functions in maintaining genomic stability and affects tumor progression. We hypothesized that genetic variations in may predict clinical outcomes in epithelial ovarian cancer (EOC).

METHODS

In this cohort study with 1,030 consecutive EOC patients, we genotyped four potentially functional polymorphisms in by the Taqman assay and evaluated their associations with patients' survival.

RESULTS

Using multivariate Cox proportional hazards regression models, we found that rs851797AG/GG genotypes were significantly associated with recurrence and cancer death (HR =1.30 and 1.38, 95% CI =1.11-1.52 and 1.02-1.88, respectively). Kaplan-Meier survival estimates showed that patients who carried rs851797AG/GG genotypes had poorer progression-free survival and poorer overall survival, compared with rs851797AA genotype carriers (log-rank test, =0.002 and 0.025, respectively). Moreover, patients with older age at menophania, advanced stage tumor, or being received incomplete cytoreduction were more likely to be recurrent and dead.

CONCLUSION

rs851797 polymorphism can predict the clinical outcomes in EOC patients. In addition, age at menophania, FIGO stage, and complete cytoreduction might be independently prognostic factors of ovarian cancer. Large studies with functional experiments are warranted to validate these findings.