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抗肾小球基底膜和C-ANCA/PR3抗体双阳性的新月体性肾小球肾炎

Crescentic glomerulonephritis with dual positive anti-GBM and C-ANCA/PR3 antibodies.

作者信息

Omotoso Bolanle A, Cathro Helen P, Balogun Rasheed A

机构信息

Department of Internal Medicine, Division of Nephrology.

Renal Unit, Department of Medicine, Obafemi Awolowo University Teaching Hospital, Ile Ife, Osun State, Nigeria.

出版信息

Clin Nephrol Case Stud. 2016 Apr 29;4:5-10. doi: 10.5414/CNCS108666. eCollection 2016.

DOI:10.5414/CNCS108666
PMID:29043135
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5438001/
Abstract

Antiglomerular basement membrane (anti-GBM) antibodies are more often accompanied by myeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA) than by proteinase 3 antineutrophil cytoplasmic antibody (PR3-ANCA). Both disease processes can affect the kidneys and/or the lungs. Patients with dual positive disease may have an atypical presentation which may delay diagnosis and treatment. Here we report a case of crescentic glomerulonephritis associated with positive PR3-ANCA and anti-GBM antibodies who underwent both lung and kidney biopsies.

摘要

抗肾小球基底膜（anti-GBM）抗体更常伴有髓过氧化物酶抗中性粒细胞胞浆抗体（MPO-ANCA），而非蛋白酶3抗中性粒细胞胞浆抗体（PR3-ANCA）。这两种疾病过程均可影响肾脏和/或肺部。双阳性疾病患者可能有非典型表现，这可能会延迟诊断和治疗。在此，我们报告一例新月体性肾小球肾炎患者，其PR3-ANCA和抗GBM抗体均呈阳性，并接受了肺和肾活检。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05c4/5438001/fd46e136e5f2/CNCS-4-005-05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05c4/5438001/1026506ded5c/CNCS-4-005-01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05c4/5438001/639a0a6a0aa9/CNCS-4-005-02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05c4/5438001/68a86448d87c/CNCS-4-005-03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05c4/5438001/af630ac13c76/CNCS-4-005-04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05c4/5438001/fd46e136e5f2/CNCS-4-005-05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05c4/5438001/1026506ded5c/CNCS-4-005-01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05c4/5438001/639a0a6a0aa9/CNCS-4-005-02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05c4/5438001/68a86448d87c/CNCS-4-005-03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05c4/5438001/af630ac13c76/CNCS-4-005-04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05c4/5438001/fd46e136e5f2/CNCS-4-005-05.jpg

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一例罕见的肺肾综合征，同时髓过氧化物酶抗中性粒细胞胞浆抗体（MPO-ANCA）、蛋白酶3（PR3）-ANCA和抗肾小球基底膜（GBM）抗体均呈阳性。
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