Aigha Idil, Raynaud Christophe
Qatar Cardiovascular Research Center, Qatar Foundation, Education City, Doha, Qatar.
Glob Cardiol Sci Pract. 2016 Mar 31;2016(1):e201606. doi: 10.21542/gcsp.2016.6.
Stem cell therapy appears to be a promising area of research for cardiac regeneration following ischemic heart failure. However, differentiation of cardiomyocytes from pluripotent stem cells, or directly from somatic cells, leads to generation of "immature" cardiomyocytes that differ from their adult counterparts in various ways. This immaturity triggers some challenges for their potential clinical use, and multiple techniques reviewed here have been developed for maturation of those cells. Nevertheless, full maturity of cardiomyocytes remains elusive and will remain the main challenge for stem cell therapy in the near future.
干细胞疗法似乎是缺血性心力衰竭后心脏再生研究中一个很有前景的领域。然而，多能干细胞或直接从体细胞分化产生的心肌细胞会生成“不成熟”的心肌细胞，这些细胞在多个方面与其成熟的对应细胞不同。这种不成熟性给它们的潜在临床应用带来了一些挑战，本文综述了多种使这些细胞成熟的技术。尽管如此，心肌细胞的完全成熟仍然难以实现，并且在不久的将来仍将是干细胞治疗的主要挑战。
