Suradi Hussam S, Kavinsky Clifford J, Hijazi Ziyad M
St Mary Medical Center, Community HealthCare Network, Hobart, IN.
Rush Center for Structural Heart Disease, Rush University Medical Center, Chicago, IL.
Glob Cardiol Sci Pract. 2016 Jun 30;2016(2):e201617. doi: 10.21542/gcsp.2016.17.
Chronic mitral regurgitation (MR) is the most common cardiac valvular disease with more than 4 million people in the United States alone suffering from moderate or severe MR. Left untreated, chronic MR results in serious consequences. Surgical correction with mitral valve repair or replacement remains the mainstay of therapy for MR. Nevertheless, a large proportion of patients may not be offered treatment due to concerns over surgical risk. This unmet therapeutic need for a less invasive approach led to a marked explosion in the development of a variety of transcatheter approaches to treat mitral regurgitation in the past decade. The majority of these devices are based on principles learned from surgical mitral valve repair techniques. Inspired by the Alfieri surgical technique, the MitraClip edge-to-edge repair system is the most advanced technique with the highest safety and efficacy to date. In this review, we discuss the current status of the MitraClip repair system in the treatment of mitral regurgitation.
慢性二尖瓣反流（MR）是最常见的心脏瓣膜疾病，仅在美国就有超过400万人患有中度或重度MR。若不治疗，慢性MR会导致严重后果。二尖瓣修复或置换的手术矫正仍是MR治疗的主要手段。然而，由于担心手术风险，很大一部分患者可能无法接受治疗。过去十年间，这种对侵入性较小方法的未满足治疗需求导致了多种经导管治疗二尖瓣反流方法的显著发展。这些装置大多基于从外科二尖瓣修复技术中学到的原理。受阿尔菲耶里手术技术启发，MitraClip缘对缘修复系统是迄今为止安全性和有效性最高的最先进技术。在本综述中，我们讨论了MitraClip修复系统在治疗二尖瓣反流方面的现状。
