Anderson Bradley, Smyrk Thomas, Sweester Seth
Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN.
Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN.
ACG Case Rep J. 2017 Oct 11;4:e113. doi: 10.14309/crj.2017.113. eCollection 2017.
Cowden syndrome (CS) represents one possible phenotype of the gene mutation, and it can cause hamartomas throughout the gastrointestinal tract, with a predisposition for malignancy. Fibroblastic polyps have not been associated with CS. A 45-year-old woman with CS presenting for colonoscopic surveillance was found to have multiple sessile polyps throughout the transverse, descending, and sigmoid colon, all 2-5 mm in diameter. Based on the morphologic features and the immunohistochemical profile, these lesions were classified as fibroblastic polyps. This polyp subtype is recognized as a benign process of the colonic mucosa but is a novel histologic observation in the setting of CS.
考登综合征（CS）是基因突变的一种可能表型，可导致全胃肠道错构瘤，并有恶变倾向。纤维母细胞性息肉与CS无关。一名45岁患有CS的女性接受结肠镜监测时，发现整个横结肠、降结肠和乙状结肠有多个无蒂息肉，直径均为2 - 5毫米。根据形态学特征和免疫组化结果，这些病变被分类为纤维母细胞性息肉。这种息肉亚型被认为是结肠黏膜的良性病变，但在CS背景下是一种新的组织学观察结果。
