Cai Xiangdong, Liu Zhao, Zhao Sha, Song Chen, Dong Shouliang, Xiao Jianxi
State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China.
Chem Commun (Camb). 2017 Oct 31;53(87):11905-11908. doi: 10.1039/c7cc06056d.
We herein report the construction of a novel single stranded fluorescent collagen mimetic peptide by introducing a bulky FAM dye in the central region rather than the N terminus. Without the need for any prior thermal or ultraviolet treatment, the peptide probe can be conveniently applied to specifically target collagen in connective tissues for fluorescence imaging.
我们在此报告了一种新型单链荧光胶原蛋白模拟肽的构建方法，该方法是通过在中心区域而非N端引入一个体积较大的FAM染料来实现的。无需任何预先的热处理或紫外线处理，该肽探针即可方便地应用于特异性靶向结缔组织中的胶原蛋白进行荧光成像。
