Wang Yuanhao, Li Yuanhe, Fan Yijun, Wang Zhiguo, Tang Yefeng
School of Pharmaceutical Sciences & Comprehensive AIDS Research Center, Tsinghua University, Beijing 100084, China.
Chem Commun (Camb). 2017 Oct 31;53(87):11873-11876. doi: 10.1039/c7cc07543j.
Pd-Catalyzed denitrogenative functionalizations of benzotriazoles with alkenes and 1,3-dienes have been developed, which enable the rapid access of diverse ortho-amino styrenes and 2-vinylindolines, respectively. This study shows the great potential of benzotriazoles as a [1C]-synthon in cross-coupling reactions and an aza-[3C]-synthon in cycloaddition reactions.
已开发出钯催化苯并三唑与烯烃和 1,3 - 二烯的脱氮官能化反应，分别能够快速合成多种邻氨基苯乙烯和 2 - 乙烯基吲哚啉。该研究表明苯并三唑在交叉偶联反应中作为[1C]合成子以及在环加成反应中作为氮杂[3C]合成子具有巨大潜力。
