School of Pharmaceutical Sciences, MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Tsinghua University, Beijing 100084, China.
College of Chemical Engineering, Qinghai University, Xining 810016, China.
Molecules. 2023 Jan 2;28(1):363. doi: 10.3390/molecules28010363.
The photo-induced denitrogenative annulations of a variety of 1-alkenylbenzotriazoles were investigated. By judiciously manipulating the structural variations of 1-alkenylbenzotriazoles, two characteristic polycyclic skeletons associated with monoterpene indole alkaloids were constructed through a diverted and controllable manner. The present work not only enriches the photochemistry of 1-alkenylbenzotriazoles, but also offers a unified approach to access skeletally diverse indole alkaloid scaffolds.
研究了多种 1-烯基苯并三唑的光致脱氮环化反应。通过巧妙地控制 1-烯基苯并三唑的结构变化，以一种定向和可控的方式构建了两种与单萜吲哚生物碱相关的特征多环骨架。本工作不仅丰富了 1-烯基苯并三唑的光化学，而且为获得骨架多样的吲哚生物碱支架提供了一种统一的方法。
