Demura R, Suzuki T, Nakamura S, Komatsu H, Jibiki K, Odagiri E, Demura H, Shizume K
Radioassay Center, Tokyo Women's Medical College, Japan.
Endocrinol Jpn. 1988 Jun;35(3):385-90. doi: 10.1507/endocrj1954.35.385.
The effects of testosterone administration on testicular inhibin content and histology were studied in bilaterally cryptorchid rats, in which a marked decrease in testicular inhibin content had been observed. Mature male Wistar rats weighing approximately 300 g were made bilaterally cryptorchid by placing the testes in the abdominal cavity. Testosterone in oil, 0.1, 1.0 or 10 mg, was given i.m. each week. Testicular inhibin and testosterone content, histology and plasma LH, FSH and testosterone were studied 2 weeks later. Abnormally decreased testicular inhibin in cryptorchidism was restored toward normal by testosterone in a dose dependent manner in 2 weeks after surgery. Sertoli cell structure also recovered toward normal with increasing amount of testosterone. Decreased testicular testosterone content and Leydig cell atrophy were observed with suppressed plasma LH and FSH after testosterone. These results showed that the increased plasma concentration of testosterone had a stimulatory effect on the Sertoli cell function in cryptorchidism, in which compensated Leydig cell failure was demonstrated.
在双侧隐睾大鼠中研究了睾酮给药对睾丸抑制素含量和组织学的影响，此前已观察到这些大鼠睾丸抑制素含量显著降低。将体重约300g的成年雄性Wistar大鼠双侧隐睾，即将睾丸置于腹腔内。每周肌肉注射含0.1mg、1.0mg或10mg睾酮的油剂。2周后研究睾丸抑制素和睾酮含量、组织学以及血浆促黄体生成素（LH）、促卵泡生成素（FSH）和睾酮。隐睾症中异常降低的睾丸抑制素在术后2周内通过睾酮以剂量依赖性方式恢复至正常。随着睾酮量增加，支持细胞结构也恢复正常。睾酮给药后观察到睾丸睾酮含量降低和间质细胞萎缩，同时血浆LH和FSH受到抑制。这些结果表明，在已证实存在代偿性间质细胞功能衰竭的隐睾症中，血浆睾酮浓度升高对支持细胞功能具有刺激作用。
