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制动应激对雄性大鼠睾酮和抑制素的影响。

Effect of immobilization stress on testosterone and inhibin in male rats.

作者信息

Demura R, Suzuki T, Nakamura S, Komatsu H, Odagiri E, Demura H

机构信息

Radioassay Center, Tokyo Women's Medical College, Japan.

出版信息

J Androl. 1989 May-Jun;10(3):210-3. doi: 10.1002/j.1939-4640.1989.tb00089.x.

DOI:10.1002/j.1939-4640.1989.tb00089.x
PMID:2501259
Abstract

Adult male Wistar rats were subjected to acute and chronic immobilization stress. Changes in plasma levels of LH, FSH and testosterone and in the content of testicular inhibin and testosterone were studied. Plasma LH levels decreased significantly in response to both acute and chronic stress. Significant decreases in plasma testosterone content were also observed after chronic stress. In contrast, plasma FSH and testicular bioassayable inhibin content did not change after acute or chronic stress. These findings indicate that in male rats immobilization stress induced a dissociation in LH and FSH responses, and decreased testosterone while inhibin remained unaffected.

摘要

成年雄性Wistar大鼠遭受急性和慢性固定应激。研究了血浆中促黄体生成素(LH)、促卵泡生成素(FSH)和睾酮水平以及睾丸抑制素和睾酮含量的变化。急性和慢性应激均导致血浆LH水平显著下降。慢性应激后血浆睾酮含量也显著降低。相比之下,急性或慢性应激后血浆FSH和睾丸生物活性抑制素含量未发生变化。这些发现表明,在雄性大鼠中,固定应激诱导了LH和FSH反应的分离,降低了睾酮水平,而抑制素未受影响。

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