Wang HaiLi, Wang Chuchu, Sun Lei, Zhou Shiyuan, Wang Fengyu
Henan Provincial Research Institute for Population and Family Planning, Zhengzhou, PR China / Key Laboratory of Birth defects Prevention, National Health and Family Planning Commission, Zhengzhou, PR China.
Zhengzhou University, School of Life Science Zhengzhou, Henan Province, China.
Pak J Pharm Sci. 2017 Jul;30(4(Suppl.)):1497-1500.
To investigate the effect of bilateral oophorectomy on bone mineral density, body composition and sex hormone of peri-menopause women. 33 cases of peri-menopause women patients performed bilateral oophorectomy were chosen from xxx gynaecology and obstetrics department of xxx hospital from January 1st,2014 to Dec31th, 2014. And the 33 cases were taken as ovariectomy group. 35 women who were the naturally postmenopausal after menopause collected in clinic and in the same period with the patients of ovariectomy group were taken in control group. American GE-Lunar-Prodigy dual energy X-ray absorptiometry and chemiluminescence method were employed to detect the bone mineral density, fat content, muscle content and sex hormone of the patients in both groups at the 6th and 12th month after menostasis. There was no statistical significance on the comparative difference of bone mineral density, fat content and muscle content at the 6th and 12th month after menostasis between both groups, P>0.05. At the 6th month after menostasis, the estradiol (E2) level in ovariectomy group was significantly lower than that of control group [(14.79±22.17)U/L vs (32.74±31.02U/L)], P<0.05; at the 12th month after menostasis, it had the statistical significance for the comparative difference between the level of E2 and and follicle-stimulating hormone (FSH) in ovariectomy group and that in control group, E2: (8.09±4.38)U/L vs (25.92±3.53)U/L; FSH: (64.88±18.39)U/L vs (40.69±31.63)U/L], P<0.05. the change of E2 and FSH were the main symptom of peri-menopausal women within 12 months after bilateral oophorectomy, the decrease of E2 level had no effect on bone mineral density, fat content and muscle content.
探讨双侧卵巢切除术对围绝经期女性骨密度、身体成分及性激素的影响。选取2014年1月1日至2014年12月31日于xxx医院xxx妇产科行双侧卵巢切除术的33例围绝经期女性患者作为卵巢切除组。选取同期门诊收集的35例自然绝经后的女性作为对照组。采用美国GE-Lunar-Prodigy双能X线吸收法及化学发光法检测两组患者停经后6个月及12个月时的骨密度、脂肪含量、肌肉含量及性激素。两组停经后6个月及12个月时骨密度、脂肪含量及肌肉含量比较差异无统计学意义，P>0.05。停经后6个月时，卵巢切除组雌二醇（E2）水平显著低于对照组[（14.79±22.17）U/L vs（32.74±31.02）U/L]，P<0.05；停经后12个月时，卵巢切除组与对照组E2及促卵泡生成素（FSH）水平比较差异有统计学意义，E2：（8.09±4.38）U/L vs（25.92±3.53）U/L；FSH：（64.88±18.39）U/L vs（40.69±31.63）U/L]，P<0.05。双侧卵巢切除术后12个月内围绝经期女性E2及FSH的变化为主要表现，E2水平降低对骨密度、脂肪含量及肌肉含量无影响。
