Agbaraji V O, Scott R B, Leto S, Kingslow L W
Howard University Center for Sickle Cell Disease, Washington, D.C.
Int J Fertil. 1988 Sep-Oct;33(5):347-52.
Semen analysis was done on 50 subjects (25 patients with sickle cell anemia and 25 control subjects with normal hemoglobin genotype). The ejaculate volume, sperm motility, sperm density, and normal sperm morphology were significantly reduced in the patients when compared with the control subjects. A significant increase was also observed in the percentage of spermatids and in abnormal spermatozoa with amorphous and tapered heads in the patients' semen. These findings clearly show that there are definite abnormalities associated with semen in sickle cell anemia. Furthermore, they suggest that in addition to testicular dysfunction, there may be abnormalities in the accessory sex organs, such as the seminal vesicles and the prostate gland, particularly in view of the marked decrease in ejaculate volume of the patients.
对50名受试者进行了精液分析（25例镰状细胞贫血患者和25例血红蛋白基因型正常的对照受试者）。与对照受试者相比，患者的射精量、精子活力、精子密度和正常精子形态均显著降低。患者精液中的精子细胞百分比以及头部无定形和锥形的异常精子数量也显著增加。这些发现清楚地表明，镰状细胞贫血患者的精液存在明确异常。此外，这表明除睾丸功能障碍外，附属生殖器官如精囊和前列腺可能也存在异常，尤其是考虑到患者射精量显著减少的情况。
