血红素与患有先天性心脏病并接受心脏手术的新生儿及婴儿的血栓形成有关。
Haem is associated with thrombosis in neonates and infants undergoing cardiac surgery for congenital heart disease.
作者信息
Stolla M, Henrichs K, Cholette J M, Pietropaoli A P, Phipps R P, Spinelli S L, Blumberg N
机构信息
Department of Pathology and Laboratory Medicine, University of Rochester, Rochester, NY, USA.
Bloodworks Northwest Research Institute, Seattle, WA, USA.
出版信息
Vox Sang. 2018 Jan;113(1):72-75. doi: 10.1111/vox.12606. Epub 2017 Oct 16.
BACKGROUND
Haem levels are associated with thrombosis in a variety of diseases, as well as being a contributing cause of thrombotic events in animal models.
MATERIALS AND METHODS
We retrospectively analyzed samples from 39 children who underwent cardiac surgery with cardiopulmonary bypass, including 15 children who developed a postoperative thrombosis and 24 controls.
RESULTS
Patients who developed thrombosis postoperatively had statistically significant higher average haem levels over time (presurgery to 12 h postsurgery) compared to patients who did not develop thrombosis.
CONCLUSION
Higher cell-free total haem levels are associated with a higher risk of thrombosis in a paediatric cardiac surgical cohort.
背景
血红蛋白水平在多种疾病中与血栓形成相关，并且是动物模型中血栓形成事件的一个促成因素。
材料与方法
我们回顾性分析了39例接受体外循环心脏手术的儿童的样本，其中包括15例术后发生血栓形成的儿童和24例对照。
结果
与未发生血栓形成的患者相比，术后发生血栓形成的患者在一段时间内（术前至术后12小时）平均血红蛋白水平在统计学上显著更高。
结论
在儿科心脏手术队列中，较高的无细胞总血红蛋白水平与较高的血栓形成风险相关。
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